Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …

The β-cell is equipped with at least six voltage-gated Ca2+ (CaV) channel α1-subunits
designated CaV1. 2, CaV1. 3, CaV2. 1, CaV2. 2, CaV2. 3, and CaV3. 1. These principal …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease resulting in the
designated immune destruction of insulin producing β-cells, usually diagnosed in youth, and …

The interactions between c-Kit and its ligand, stem cell factor (SCF), play an important role in
haematopoiesis, pigmentation and gametogenesis. c-Kit is also found in the pancreas, and …

It has been well documented that there are abundant endocrine progenitor cells in the
neonatal pancreas. However, little is known of their relative proportions or even their …

Aims/hypothesis The receptor tyrosine kinase, c-Kit, and its ligand, stem cell factor, control a
variety of cellular processes, including pancreatic beta cell survival and differentiation as …

Solid tumors of the pancreas are usually neoplastic. We report on two adult patients, each
with a solid tumor of the pancreas that presented with an unusual histology and seemed to …

c-Kit tyrosine receptor kinase, a well-established stem cell marker, is expressed in a variety
of tissues including the pancreas. The involvement of c-Kit in fetal rat and human endocrine …

Stem cell factor (SCF), a progenitor cell growth factor, binds to and activates the c-Kit
receptor tyrosine kinase, which is critical for early stem cell differentiation in haematopoiesis …

La diabetes mellitus tipo 1 es una enfermedad metabólica multifactorial en la que los
mecanismos inmunológicos juegan un papel fundamental. Una vez desarrollada la …