The stand-alone pathogenicity of fowl adenoviruses (FAdVs) had long been disputed, given
the ubiquity of the viruses versus sporadic outbreaks, and variation between experimental …

Although frequently examined as a target organ for non-endocrine toxicity, histopathological
evaluation of the liver is becoming a routine component of endocrine disruption studies that …

Summary Alpha-1 antitrypsin deficiency (AATD) arises from mutations in the SERPINA1
gene encoding alpha-1 antitrypsin (AAT) that lead to AAT retention in the endoplasmic …

Objective Homozygous alpha1-antitrypsin (AAT) deficiency increases the risk for developing
cirrhosis, whereas the relevance of heterozygous carriage remains unclear. Hence, we …

Background & Aims Alpha-1 antitrypsin deficiency (AATD) is among the most common
genetic disorders. Severe AATD is caused by a homozygous mutation in the SERPINA1 …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
Western countries, and the gut-liver axis is implicated in liver disease pathogenesis. We …

METHODS: Total (K18-M65) and caspase-cleaved K18 (K18-M30) were quantified in
pretreatment sera from 824 patients enrolled in the Steroids or Pentoxifylline for Alcoholic …

Obesity commonly leads to hepatic steatosis, which often provokes lipotoxic injuries to
hepatocytes that cause nonalcoholic steatohepatitis (NASH). NASH, in turn, is associated …

The study determined if administration of Vernonia amygdalina and Carica papaya plants
provides synergistic effects in ameliorating plasmodium infection in mice. Thirty mice (17.88 …

Hepatocytes synthesise the majority of serum proteins. This production occurs in the
endoplasmic reticulum (ER) and is adjusted by complex local and systemic regulatory …