The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-
end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable …

Publisher Summary This chapter focuses on properties and functions of interleukin-10. IL10
inhibits several macrophage functions, including some microbicidal properties and …

Osteoclasts, the multinucleated cells that resorb bone, develop from hematopoietic cells of
monocyte/macrophage lineage. Osteoclast-like cells (OCLs) are formed by coculturing …

The ob gene product, leptin, is an important circulating signal for the regulation of body
weight. To identify high affinity leptin-binding sites, we generated a series of leptin-alkaline …

Mitogen-activated protein (MAP) kinase cascades are activated in response to various
extracellular stimuli, including growth factors and environmental stresses. A MAP kinase …

Abstract CD25+ CD4+ regulatory T cells in normal animals are engaged in the maintenance
of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis …

SINGLE neurons can signal subtle changes in the sensory environment with surprising
fidelity, often matching the perceptual sensitivity of trained psychophysical observers1–10 …

The 2; 5 chromosomal translocation is frequently associated with anaplastic large cell
lymphomas (ALCLs). The translocation creates a fusion gene consisting of the alk …

The morphogenesis and remodeling of bone depends on the integrated activity of
osteoblasts that form bone and osteoclasts that resorb bone. We previously reported the …

Dimerization and oligomerization are general biological control mechanisms contributing to
the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and …