Previous studies have reported conflicting results in terms of acute effects of cannabis in
man. Independently of other factors, such discrepancy may be attributable to the different …

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a
human-relevant platform for cardiac function assessment. Alternative assays using hiPSC …

The discovery that half of the mammalian protein-coding genome is regulated by the
circadian clock has clear implications for medicine. Recent studies demonstrated that the …

Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …

Nanoplastics with small particle sizes and high surface area/volume ratios easily absorb
environmental pollutants and affect their bioavailability. In this study, polystyrene nanoplastic …

Phthalates and bisphenols are high production volume chemicals that are used in the
manufacturing of consumer and medical products. Given the ubiquity of bisphenol and …

Conventional tissue engineering, cell therapy, and current medical approaches were shown
to be successful in reducing mortality rate and complications caused by cardiovascular …

Nonmedical use of prescription and nonprescription drugs is a worldwide epidemic, rapidly
growing in magnitude with deaths because of overdose and chronic use. A vast majority of …

The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …

Synthetic cathinones (SCat) are amphetamine-like psychostimulants that emerged onto drug
markets as “legal” alternatives to illicit drugs such as ecstasy, cocaine, and amphetamines …