A large part of the mammalian genome is transcribed into noncoding RNAs. Long
noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators of gene …

High throughput sequencing technologies have become essential in studies on genomics,
epigenomics, and transcriptomics. Although sequencing information has traditionally been …

Mitochondrial morphology is crucial for tissue homeostasis, but its role in cell differentiation
is unclear. We found that mitochondrial fusion was required for proper cardiomyocyte …

Rationale: Accurate and comprehensive de novo transcriptome profiling in heart is a central
issue to better understand cardiac physiology and diseases. Although significant progress …

In vitro models incorporating the complexity and function of adult human tissues are highly
desired for translational research. Whilst vital slices of human myocardium approach these …

The vast majority of mammalian DNA does not encode for proteins but instead is transcribed
into noncoding (nc) RNAs having diverse regulatory functions. The poorly characterized …

The control of force production in vascular smooth muscle is critical to the normal regulation
of blood flow and pressure, and altered regulation is common to diseases such as …

In order to understand the role of microRNAs (miRNAs) in vascular physiopathology, we
took advantage of deep-sequencing techniques to accurately and comprehensively profile …

Rationale: MicroRNA-499 and other members of the myomiR family regulate myosin
isoforms in pressure-overload hypertrophy. miR-499 expression varies in human disease …

Background—Genetic studies of cardiomyopathy and heart failure have limited throughput
in mammalian models. Adult zebrafish have been recently pursued as a vertebrate model …