In Silico Identification of Peptides with PPARγ Antagonism in Protein Hydrolysate from Rice (Oryza sativa)
FJ Ruiz-López, BA Espinosa-Rodríguez… - Pharmaceuticals, 2023 - mdpi.com
At least half the population in industrialized countries suffers from obesity due to excessive
accumulation of adipose tissue. Recently, rice (Oryza sativa) proteins have been considered …
accumulation of adipose tissue. Recently, rice (Oryza sativa) proteins have been considered …
The relevance of thimet oligopeptidase in the regulation of energy metabolism and diet-induced obesity
Thimet oligopeptidase (EC 3.4. 24.15; EP24. 15; THOP1) is a potential therapeutic target, as
it plays key biological functions in processing biologically functional peptides. The structural …
it plays key biological functions in processing biologically functional peptides. The structural …
Bioactive Peptides from Meretrix lusoria Enzymatic Hydrolysate as a Potential Treatment for Obesity in db/db Mice
R Chilakala, HJ Moon, MS Jung, JW Han, KH Ko… - Nutrients, 2024 - mdpi.com
Obesity is acknowledged as a significant risk factor for cardiovascular disease, often
accompanied by increased inflammation and diabetes. Bioactive peptides derived from …
accompanied by increased inflammation and diabetes. Bioactive peptides derived from …
Inhibition of glutathione and s-allyl glutathione on pancreatic lipase: Analysis through in vitro kinetics, fluorescence spectroscopy and in silico docking
P Thayumanavan, S Nallaiyan, C Loganathan… - International Journal of …, 2020 - Elsevier
Inhibition of pancreatic lipase (PL) is considered one of the important therapeutic
interventions against obesity. In the present study, the inhibition of porcine (mammalian) PL …
interventions against obesity. In the present study, the inhibition of porcine (mammalian) PL …
Heterologous Expression of the Class IIa Bacteriocins, Plantaricin 423 and Mundticin ST4SA, in Escherichia coli Using Green Fluorescent Protein as a Fusion Partner
The antilisterial class IIa bacteriocins, plantaricin 423 and mundticin ST4SA, have previously
been purified from the cell-free supernatants of Lactobacillus plantarum 423 and …
been purified from the cell-free supernatants of Lactobacillus plantarum 423 and …
Heterocycles as a peptidomimetic scaffold: solid-phase synthesis strategies
A Abdildinova, MJ Kurth, YD Gong - Pharmaceuticals, 2021 - mdpi.com
Peptidomimetics are a privileged class of pharmacophores that exhibit improved
physicochemical and biological properties. Solid-phase synthesis is a powerful tool for …
physicochemical and biological properties. Solid-phase synthesis is a powerful tool for …
Bioactive peptides derived from quinoa protein: fabrication, antioxidant activities, and in vitro digestion profiles
L Gu, N Peng, S Chen, DJ McClements, Z Tang… - Journal of Food …, 2024 - Springer
Quinoa protein is increasingly being used a source of plant protein in the food industry
because of its high nutrient value, good digestibility, and gluten-free nature. However, its …
because of its high nutrient value, good digestibility, and gluten-free nature. However, its …
Encapsulation of lipids as emulsion-alginate beads reduces food intake: A randomized placebo-controlled cross-over human trial in overweight adults
MN Corstens, FJ Troost, AME Alleleyn, T Klaassen… - Nutrition Research, 2019 - Elsevier
The objective of this study was to investigate the efficacy of lipid emulsions encapsulated in
calcium-alginate beads in reducing food intake and appetite sensations. These emulsion …
calcium-alginate beads in reducing food intake and appetite sensations. These emulsion …
Biaryl carboxamide‐based peptidomimetics analogs as potential pancreatic lipase inhibitors for treating obesity
V Pandey, PA Adhikrao, GM Motiram… - Archiv der …, 2024 - Wiley Online Library
Abstract A series of 1, 1′‐biphenyl‐3‐carboxamide and furan‐phenyl‐carboxamide
analogs were synthesized using an optimized scheme and confirmed by 1H and 13C …
analogs were synthesized using an optimized scheme and confirmed by 1H and 13C …
[HTML][HTML] Assessing the performance of new chromatographic technologies for the separation of peptide epimeric impurities: the case of Icatibant
G Mazzoccanti, S Manetto, M Bassan, M Macis… - European Journal of …, 2024 - Elsevier
The biopharmaceutical industry faces the challenge of efficiently characterising impurity
profiles of therapeutical peptides, also due to their complex polar and ionisable attributes …
profiles of therapeutical peptides, also due to their complex polar and ionisable attributes …