Health care is transitioning from genetics to genomics, in which single-gene testing for
diagnosis is being replaced by multi-gene panels, genome-wide sequencing, and other …

Individual genome-wide polygenic risk scores (GPSs) for assessing disease susceptibility
have been shown to yield both reliable and clinically meaningful results. However, certain …

During the course of biomedical research, researchers sometimes obtain information on
participants that is outside the aim of the study but may nonetheless be relevant to the …

The concept of “personalized medicine” or “precision medicine” has been discussed in
earnest at least since the official launch of the Human Genome Project in 1990. 1 …

Ethicists, regulators and researchers have struggled with the question of whether incidental
findings in genomics studies should be disclosed to participants. In the ethical debate, a …

Predicting risk of death based on personalised and objective clinical indicators is an
improvement over intuition and clinical judgement. Risk assessment can benefit clinicians …

Determining what constitutes an anticipatable incidental finding (IF) from clinical research
and defining whether, and when, this IF should be returned to the participant have been …

Imagine how you would feel if you were on a dinner date (things are going smoothly) then,
all of a sudden, a Mariachi group stops by your table and plays their music for the next five …

Imagine applying for a job, and as part of your application process, your prospective
employer asks for a photograph. You, as an eager candidate, comply with the request and …

Aims: To investigate the attitudes of patients toward the return of individual research results
from scientific research with residual tissue. Methods and Findings: We recruited 1319 …