Designing improved active peptides for therapeutic approaches against infectious diseases
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …
few decades, pathogenic microorganisms' resistance to conventional drugs has been …
[HTML][HTML] Membrane sculpting by curved DNA origami scaffolds
HG Franquelim, A Khmelinskaia, JP Sobczak… - Nature …, 2018 - nature.com
Membrane sculpting and transformation is essential for many cellular functions, thus being
largely regulated by self-assembling and self-organizing protein coats. Their functionality is …
largely regulated by self-assembling and self-organizing protein coats. Their functionality is …
Applications of biosensing atomic force microscopy in monitoring drug and nanoparticle delivery
C Lamprecht, P Hinterdorfer, A Ebner - Expert Opinion on Drug …, 2014 - Taylor & Francis
Introduction: The therapeutic effects of medicinal drugs not only depend on their properties,
but also on effective transport to the target receptor. Here we highlight recent developments …
but also on effective transport to the target receptor. Here we highlight recent developments …
[HTML][HTML] Reversible membrane deformations by straight DNA origami filaments
Membrane-active cytoskeletal elements, such as FtsZ, septin or actin, form filamentous
polymers able to induce and stabilize curvature on cellular membranes. In order to emulate …
polymers able to induce and stabilize curvature on cellular membranes. In order to emulate …
[HTML][HTML] Psd1 Effects on Candida albicans Planktonic Cells and Biofilms
S Gonçalves, PM Silva, MR Felício… - Frontiers in cellular …, 2017 - frontiersin.org
Candida albicans is an important human pathogen, causing opportunistic infections. The
adhesion of planktonic cells to a substrate is the first step for biofilm development. The …
adhesion of planktonic cells to a substrate is the first step for biofilm development. The …
Structural diversity of photoswitchable sphingolipids for optodynamic control of lipid microdomains
N Hartrampf, SM Leitao, N Winter, H Toombs-Ruane… - Biophysical journal, 2023 - cell.com
Sphingolipids are a structurally diverse class of lipids predominantly found in the plasma
membrane of eukaryotic cells. These lipids can laterally segregate with other rigid lipids and …
membrane of eukaryotic cells. These lipids can laterally segregate with other rigid lipids and …
[HTML][HTML] 25-Hydroxycholesterol effect on membrane structure and mechanical properties
MM Domingues, B Gomes, A Hollmann… - International Journal of …, 2021 - mdpi.com
Cholesterol is responsible for the plasticity of plasma membranes and is involved in
physiological and pathophysiological responses. Cholesterol homeostasis is regulated by …
physiological and pathophysiological responses. Cholesterol homeostasis is regulated by …
[HTML][HTML] Acyl-chain saturation regulates the order of phosphatidylinositol 4, 5-bisphosphate nanodomains
L Borges-Araújo, MM Domingues, A Fedorov… - Communications …, 2021 - nature.com
Abstract Phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) plays a critical role in the
regulation of various plasma membrane processes and signaling pathways in eukaryotes. A …
regulation of various plasma membrane processes and signaling pathways in eukaryotes. A …
Atomic force microscopy-based bioanalysis for the study of disease
Atomic force microscopy (AFM) has emerged as a robust and well-tested method to image
and probe living systems. Atomic force microscopy, one of many types of scanning probe …
and probe living systems. Atomic force microscopy, one of many types of scanning probe …
Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture
A Hollmann, S Gonçalves, MT Augusto… - … , Biology and Medicine, 2015 - Elsevier
Targeting membranes of enveloped viruses represents an exciting new paradigm to explore
on the development of broad-spectrum antivirals. Recently, broad-spectrum small-molecule …
on the development of broad-spectrum antivirals. Recently, broad-spectrum small-molecule …