Designing improved active peptides for therapeutic approaches against infectious diseases

B Gomes, MT Augusto, MR Felício, A Hollmann… - Biotechnology …, 2018 - Elsevier
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …

[HTML][HTML] Membrane sculpting by curved DNA origami scaffolds

HG Franquelim, A Khmelinskaia, JP Sobczak… - Nature …, 2018 - nature.com
Membrane sculpting and transformation is essential for many cellular functions, thus being
largely regulated by self-assembling and self-organizing protein coats. Their functionality is …

Applications of biosensing atomic force microscopy in monitoring drug and nanoparticle delivery

C Lamprecht, P Hinterdorfer, A Ebner - Expert Opinion on Drug …, 2014 - Taylor & Francis
Introduction: The therapeutic effects of medicinal drugs not only depend on their properties,
but also on effective transport to the target receptor. Here we highlight recent developments …

[HTML][HTML] Reversible membrane deformations by straight DNA origami filaments

HG Franquelim, H Dietz, P Schwille - Soft Matter, 2021 - pubs.rsc.org
Membrane-active cytoskeletal elements, such as FtsZ, septin or actin, form filamentous
polymers able to induce and stabilize curvature on cellular membranes. In order to emulate …

[HTML][HTML] Psd1 Effects on Candida albicans Planktonic Cells and Biofilms

S Gonçalves, PM Silva, MR Felício… - Frontiers in cellular …, 2017 - frontiersin.org
Candida albicans is an important human pathogen, causing opportunistic infections. The
adhesion of planktonic cells to a substrate is the first step for biofilm development. The …

Structural diversity of photoswitchable sphingolipids for optodynamic control of lipid microdomains

N Hartrampf, SM Leitao, N Winter, H Toombs-Ruane… - Biophysical journal, 2023 - cell.com
Sphingolipids are a structurally diverse class of lipids predominantly found in the plasma
membrane of eukaryotic cells. These lipids can laterally segregate with other rigid lipids and …

[HTML][HTML] 25-Hydroxycholesterol effect on membrane structure and mechanical properties

MM Domingues, B Gomes, A Hollmann… - International Journal of …, 2021 - mdpi.com
Cholesterol is responsible for the plasticity of plasma membranes and is involved in
physiological and pathophysiological responses. Cholesterol homeostasis is regulated by …

[HTML][HTML] Acyl-chain saturation regulates the order of phosphatidylinositol 4, 5-bisphosphate nanodomains

L Borges-Araújo, MM Domingues, A Fedorov… - Communications …, 2021 - nature.com
Abstract Phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) plays a critical role in the
regulation of various plasma membrane processes and signaling pathways in eukaryotes. A …

Atomic force microscopy-based bioanalysis for the study of disease

KC Morton, LA Baker - Analytical Methods, 2014 - pubs.rsc.org
Atomic force microscopy (AFM) has emerged as a robust and well-tested method to image
and probe living systems. Atomic force microscopy, one of many types of scanning probe …

Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture

A Hollmann, S Gonçalves, MT Augusto… - … , Biology and Medicine, 2015 - Elsevier
Targeting membranes of enveloped viruses represents an exciting new paradigm to explore
on the development of broad-spectrum antivirals. Recently, broad-spectrum small-molecule …