Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA
methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and …

Abnormal birthweight is associated with increased risk for cardiometabolic diseases in later
life. Although the placenta is critical to fetal development and later life health, it has not been …

Background Genome-wide association study (GWAS) single nucleotide polymorphisms
(SNPs) are known to preferentially co-locate to active regulatory elements in tissues and cell …

It remains elusive whether some of the associations identified in genome-wide association
studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on …

Rationale: Methylation integrates factors present at birth and modifiable across the lifespan
that can influence pulmonary function. Studies are limited in scope and replication …

Background Ambient air pollution is associated with numerous adverse health outcomes,
but the underlying mechanisms are not well understood; epigenetic effects including altered …

Background Epigenome-wide association studies using DNA methylation have the potential
to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk …

Background While smoking is known to associate with development of multiple diseases,
the underlying mechanisms are still poorly understood. Tobacco smoking can modify the …

Background Smoking impacts DNA methylation, but data are lacking on smoking-related
differential methylation by sex or dietary intake, recent smoking cessation (< 1 year) …

Powerful new technologies for perturbing genetic elements have recently expanded the
study of genetic interactions in model systems ranging from yeast to human cell lines …