Background Copper and lipid metabolism are intimately linked, sharing a complex, inverse
relationship in the periphery (outside of the central nervous system), which remains to be …

The essential transition metal copper is important in lipid metabolism, redox balance, iron
mobilization, and many other critical processes in eukaryotic organisms. Genetic diseases …

The NLRP3 inflammasome is an important regulator of inflammation and immunity. It is a
multimolecular platform formed within cells that facilitates the activation of proinflammatory …

Copper is a required metal nutrient for life, but global or local alterations in its homeostasis
are linked to diseases spanning genetic and metabolic disorders to cancer and …

Copper deficiency has emerged to be associated with various lipid metabolism diseases,
including non-alcoholic fatty liver disease (NAFLD). However, the mechanisms that dictate …

The essential trace mineral copper plays important roles in human physiology and
pathophysiology. Disruption of copper homeostasis may underlie the development of …

Datasets comprising simultaneous measurements of many essential metals in Alzheimer's
disease (AD) brain are sparse, and available studies are not entirely in agreement. To …

Micronutrients include electrolytes, minerals, vitamins, and carotenoids, and are required in
microgram or milligram quantities for cellular metabolism. The liver plays an important role in …

Many metals have biological functions and play important roles in human health. Copper
(Cu) is an essential metal that supports normal cellular physiology. Significant research …

Wilson disease (WD) is a genetic disorder of copper homeostasis, caused by deficiency of
the copper transporter ATP7B. Gene therapy with recombinant adeno-associated vectors …