Crystallization is one of the most important unit operations used for the separation and
purification of crystalline solid products. Appropriate design and control of the crystallization …

Continuous crystallization has always been a hot topic in industrial crystallization. Many
efforts have been made to improve the continuous crystallization, either by designing novel …

This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …

Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Crystallization is an important unit operation in the pharmaceutical industry. At present, most
pharmaceutical crystallization processes are performed in batches. However, due to product …

Continuous crystallization is an attractive approach for the delivery of consistent particles
with specified critical quality attributes (CQAs), which are attracting increased interest for the …

Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …

Crystallization, as a solid–liquid separation process, is employed to purify and isolate a
great diversity of crystalline pharmaceutical products. In recent years, continuous …

This work focuses on modeling and control of a continuous plug flow crystallizer (PFC) used
to produce tetragonal hen-egg-white (HEW) lysozyme crystals and proposes an optimization …

Size, shape, and polymorphic form are the critical attributes of crystalline particles and
represent the major focus of today's crystallization process design. This work demonstrates …