[HTML][HTML] Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics
JL Hu, AL Huang - Virologica Sinica, 2023 - Elsevier
The achievement of a functional cure for chronic hepatitis B (CHB) remains limited to a
minority of patients treated with currently approved drugs. The primary objective in …
minority of patients treated with currently approved drugs. The primary objective in …
The synthesis and preliminary immunological evaluation of a dual-adjuvant SARS-CoV-2 RBD vaccine: Covalent integration of TLR7/8 and iNKT cell agonists
Y Xu, J Yang, X Meng, S Meng, T Sun, N Ding… - International Journal of …, 2024 - Elsevier
Covalently linking an adjuvant to an antigenic protein enhances its immunogenicity by
ensuring a synergistic delivery to the immune system, fostering a more robust and targeted …
ensuring a synergistic delivery to the immune system, fostering a more robust and targeted …
Design, synthesis and biological evaluation of quinazoline and pyrrolo [3, 2-d] pyrimidine derivatives as TLR7 agonists for antiviral agents
Y Song, W Fan, C Yao, H Wang, X Lu… - Organic & …, 2024 - pubs.rsc.org
Pattern recognition receptors (PRRs) play a critical role in the innate immune response, and
toll-like receptor 7 (TLR7) is an important member of PRRs. Although several TLR7 agonists …
toll-like receptor 7 (TLR7) is an important member of PRRs. Although several TLR7 agonists …
Strategic development of a self-adjuvanting SARS-CoV-2 RBD vaccine: From adjuvant screening to enhanced immunogenicity with a modified TLR7 agonist
X Meng, Y Xu, J Yang, S Meng, N Ding, T Sun… - International …, 2024 - Elsevier
Adjuvants enhance the body's immune response to a vaccine, often leading to better
protection against diseases. Monophosphoryl lipid A analogues (MPLA, TLR4 agonists), α …
protection against diseases. Monophosphoryl lipid A analogues (MPLA, TLR4 agonists), α …