Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

Immunotherapy has revolutionized the contemporary oncology landscape, with durable
responses possible across a range of cancer types. However, the majority of cancer patients …

Methods capable of distributing antitumor therapeutics uniformly and durably throughout an
entire tumor would be of great significance in maximizing their treatment efficacy, but they …

Direct injection of therapies into tumors has emerged as an administration route capable of
achieving high local drug exposure and strong anti-tumor response. A diverse array of …

Lipid nanoparticles (LNPs) are a clinically relevant way to deliver therapeutic mRNA to
hepatocytes in patients. However, LNP-mRNA delivery to end-stage solid tumors such as …

Abstract Treatment of metastatic cancer is one of the biggest challenges in anticancer
therapy. Curcumin is interesting nature polyphenolic compound with unique biological and …

Cancer immunotherapy (CI) represented by immune checkpoint inhibitors (ICIs) presents a
new paradigm for cancer treatment. However, the types of cancer that attain a therapeutic …

Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer membrane-
bound vesicles which encapsulate bioactive molecules, such as nucleic acids, proteins, and …

Triple negative breast cancer (TNBC) is the most dangerous subtype of breast cancer
accompanying by unfavorable prognosis due to lack of specific therapeutic targets …

Introduction On-target, off-tumor toxicity severely limits systemic dosing of cytokines and
agonist antibodies for cancer. Intratumoral administration is increasingly being explored to …