The heterochronic pathway of C. elegans is the most well-characterized system to date for
controlling the sequence and timing of developmental events. However, we still have critical …

The nematode Caenorhabditis briggsae (C. briggsae) is routinely used in genetic and
evolutionary studies involving its well-known cousin, C. elegans. The two species are …

Background Mutations in gene regulatory networks often lead to genetic divergence without
impacting gene expression or developmental patterning. The rules governing this process of …

Natural Selection describes how species have evolved differentially, but it is descriptive, non-
mechanistic. What mechanisms does Nature use to accomplish this feat? One known way in …

The environment plays a crucial role in the developing organism, first in defining the
developmental trajectory from genotype to phenotype, then by modifying that trajectory by …

Transcription factors are defined by their DNA-binding domains (DBDs). The binding
affinities and specificities of a transcription factor to its DNA binding sites can be used by an …

Dissecting the signaling pathways that control the alteration of morphogenic processes
during embryonic development requires robust and sensitive metrics. Embryonic elongation …

JOURNAL OF CREATION 28 (3) 2014|| PAPERS be used, but the most widely accepted is
the ability of the two species to form hybrid offspring. 4 This is based on the understanding …

Gene loss often contributes to the evolution of adaptive traits. Conversely, null mutations
frequently reveal no obvious phenotypic consequences. How pervasive is gene loss, what …

Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …