Hypertension-associated cerebral small vessel disease is a common finding in older people.
Strongly associated with age and hypertension, small vessel disease is found at autopsy in …

Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …

Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading
cause of cognitive impairment, the mechanisms of which remain poorly understood. In the …

Diseases of the central nervous system (CNS) are often associated with vascular
disturbances or inflammation and frequently both. Consequently, endothelial cells and …

Cerebral ischemia is a devastating condition that results in impaired blood flow in the brain
leading to acute brain injury. As the most common form of stroke, occlusion of cerebral …

Cerebrovascular diseases are a major cause of stroke and dementia, both requiring long-
term care. These diseases involve multiple pathophysiologies, with mitochondrial …

Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …

This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and
peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia …

Dementia affects almost 50 million adults worldwide, and remains a major cause of death
and disability. Hypertension is a leading risk factor for dementia, including Alzheimer …

Mechanosensors are emerging players responding to hemodynamic and physical inputs.
Their significance in the central nervous system remains relatively uncharted. Using human …