The transient receptor potential vanilloid 4 (TRPV4) channel is a non-selective cation
channel that is mostly permeable to calcium (Ca2+), which participates in intracellular Ca2+ …

The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …

Under physiological conditions, the widely expressed calcium-activated TRPM4 channel
conducts sodium into cells. This sodium influx depolarizes the plasma membrane and …

Cardiac arrhythmias pose a major threat to a patient's health, yet prove to be often difficult to
predict, prevent and treat. A key mechanism in the occurrence of arrhythmias is disturbed …

Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP
superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular …

Sudden cardiac death is a sudden, unexpected death developed by one of the many
different causes of cardiac arrest that occur within 1 hour of the onset of new symptoms …

Abstract Transient Receptor Potential (TRP) channels, integral membrane proteins, play a
critical role in various physiological processes and are implicated in numerous hereditary …

Background Cardiac conduction disorder (CCD) in patients< 50 years old is a rare and
mostly unknown condition. Objective We aimed to assess clinical characteristics and genetic …

TRPM4 is a calcium‐activated, voltage‐modulated, nonselective ion channel widely
expressed in various cells and tissues. TRPM4 regulates the influx of sodium ions, thus …

在青壮年人群中, 遗传性心脏病导致的死亡在心脏性猝死(sudden cardiac death, SCD)
中占重要比例. 遗传性心脏病可分为遗传性结构性心脏病和离子通道病. 遗传性结构性心脏病 …