Mechanistic pathways of sex differences in cardiovascular disease

V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2016 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

Protective effects of estrogen on cardiovascular disease mediated by oxidative stress

D Xiang, Y Liu, S Zhou, E Zhou… - Oxidative medicine and …, 2021 - Wiley Online Library
Perimenopause is an important stage of female senescence. Epidemiological investigation
has shown that the incidence of cardiovascular disease in premenopausal women is lower …

The expanding complexity of estrogen receptor signaling in the cardiovascular system

S Menazza, E Murphy - Circulation research, 2016 - Am Heart Assoc
Estrogen has important effects on cardiovascular function including regulation of vascular
function, blood pressure, endothelial relaxation, and the development of hypertrophy and …

Sex differences in inflammation during atherosclerosis

DL Fairweather - Clinical Medicine Insights: Cardiology, 2014 - journals.sagepub.com
Atherosclerosis is the leading cause of death in the United States and worldwide, yet more
men die from atherosclerosis than women, and at a younger age. Women, on the other …

Sexual dimorphism in autoimmune disease

PA McCombe, JM Greer… - Current molecular …, 2009 - ingentaconnect.com
We briefly survey the concept of autoimmunity and nominate the range of autoimmune
diseases that include multisystemic and organ-specific disorders, and cite prevalences of …

Estrogen receptor activation and cardioprotection in ischemia reperfusion injury

AM Deschamps, E Murphy, J Sun - Trends in cardiovascular medicine, 2010 - Elsevier
Premenopausal females have a comparably lower incidence of cardiovascular disease than
their male counterparts. Although estrogen and activation of estrogen receptors (ERs) have …

Mitochondrial connexin 43 in sex-dependent myocardial responses and estrogen-mediated cardiac protection following acute ischemia/reperfusion injury

M Wang, K Smith, Q Yu, C Miller, K Singh… - Basic research in …, 2020 - Springer
Preserving mitochondrial activity is crucial in rescuing cardiac function following acute
myocardial ischemia/reperfusion (I/R). The sex difference in myocardial functional recovery …

Gender differences in cardiac ischemic injury and protection—experimental aspects

B Ostadal, I Netuka, J Maly, J Besik… - Experimental biology …, 2009 - journals.sagepub.com
This review summarizes some available information on gender differences of myocardial
injury with particular attention to experimental approach. It has been observed that …

Estrogen receptor β ligands: recent advances and biomedical applications

F Minutolo, M Macchia… - Medicinal research …, 2011 - Wiley Online Library
Recent work elucidating the role that the estrogen receptor β (ERβ), a member of the nuclear
receptor superfamily, plays in regulating various physiological functions has highlighted the …

Non-genomic effects of estrogen on cell homeostasis and remodeling with special focus on cardiac ischemia/reperfusion injury

R Puglisi, G Mattia, A Carè, G Marano… - Frontiers in …, 2019 - frontiersin.org
This review takes into consideration the main mechanisms involved in cellular remodeling
following an ischemic injury, with special focus on the possible role played by non-genomic …