Multicomponent peptide assemblies

DM Raymond, BL Nilsson - Chemical Society Reviews, 2018 - pubs.rsc.org
Self-assembled peptide nanostructures have been increasingly exploited as functional
materials for applications in biomedicine and energy. The emergent properties of these …

Synthesis, self-assembly, and biomedical applications of antimicrobial peptide–polymer conjugates

H Sun, Y Hong, Y Xi, Y Zou, J Gao, J Du - Biomacromolecules, 2018 - ACS Publications
Antimicrobial peptides (AMPs) have been attracting much attention due to their excellent
antimicrobial efficiency and low rate in driving antimicrobial resistance (AMR), which has …

Design of polymeric carriers for intracellular peptide delivery in oncology applications

S Lv, M Sylvestre, AN Prossnitz, LF Yang… - Chemical …, 2021 - ACS Publications
In recent decades, peptides, which can possess high potency, excellent selectivity, and low
toxicity, have emerged as promising therapeutics for cancer applications. Combined with an …

Poly (amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines

M Skwarczynski, G Zhao, JC Boer, V Ozberk… - Science …, 2020 - science.org
To be optimally effective, peptide-based vaccines need to be administered with adjuvants.
Many currently available adjuvants are toxic, not biodegradable; they invariably invoke …

Antimicrobial peptides: the promising therapeutics for cutaneous wound healing

F Miao, Y Li, Z Tai, Y Zhang, Y Gao… - Macromolecular …, 2021 - Wiley Online Library
Chronic wound infections have caused an increasing number of deaths and economic
burden, which necessitates wound treatment options. Hitherto, the development of functional …

Supramolecular assembly of a trivalent peptide hydrogel vaccine for cancer immunotherapy

H Song, Q Su, Y Nie, C Zhang, P Huang, S Shi, Q Liu… - Acta Biomaterialia, 2023 - Elsevier
Vaccination shows great promise in cancer immunotherapy. However, the induction of
robust and broad therapeutic CD8 T cell immunity against tumors is challenging due to the …

Supramolecular self-assembled peptide-based vaccines: current state and future perspectives

T Abdullah, K Bhatt, LJ Eggermont, N O'Hare… - Frontiers in …, 2020 - frontiersin.org
Despite the undeniable success of vaccination programs in preventing diseases, effective
vaccines against several life-threatening infectious pathogens such as human …

Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances

J Zhang, J Fan, M Skwarczynski… - International Journal …, 2022 - Taylor & Francis
Persistent infection with high-risk human papillomaviruses (HPVs), such as HPV-16 and
HPV-18, can induce cervical cancer in humans. The disease carries high morbidity and …

Active immunotherapy for TNF-mediated inflammation using self-assembled peptide nanofibers

C Mora-Solano, Y Wen, H Han, J Chen, AS Chong… - Biomaterials, 2017 - Elsevier
Active immunotherapies raising antibody responses against autologous targets are
receiving increasing interest as alternatives to the administration of manufactured …

Self-assembly as a molecular strategy to improve immunotherapy

E Froimchuk, ST Carey, C Edwards… - Accounts of chemical …, 2020 - ACS Publications
Conspectus Immunotherapies harness an individual's immune system to battle diseases
such as cancer and autoimmunity. During cancer, the immune system often fails to detect …