Despite major improvements in outcome over the past decades, acute myeloid leukemia
(AML) remains a life-threatening malignancy in children, with current survival rates of∼ …

Pediatric acute myeloid leukemia (AML) represents 15%–20% of all pediatric acute
leukemias. Survival rates have increased over the past few decades to~ 70%, due to …

Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …

The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute
myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that …

Summary The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in
the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) …

Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis in
mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective …

Background Cancer patients can achieve dramatic responses to chemotherapy yet retain
resistant tumor cells, which ultimately results in relapse. Although xenograft model studies …

Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently
defined by recurrent cytogenetic abnormalities, including rearrangements involving the core …

Purpose The Microarray Innovations in Leukemia study assessed the clinical utility of gene
expression profiling as a single test to subtype leukemias into conventional categories of …

Leukaemias and other cancers possess a rare population of cells capable of the limitless
self-renewal necessary for cancer initiation and maintenance,,,,,,. Eradication of these …