TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …

Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …

Mitochondrial damage causes mitochondrial DNA (mtDNA) release to activate the type I
interferon (IFN-I) response via the cGAS-STING pathway. mtDNA-induced inflammation …

Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that
forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor neurons in …

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is
classically thought to impact the motor system. Over the past 20 years, research has started …

Mitochondrial dysfunction is becoming one of the main pathology factors involved in the
etiology of neurological disorders. Recently, mutations of the coiled-coil-helix-coiled-coil …

During aging, muscle gradually undergoes sarcopenia, the loss of function associated with
loss of mass, strength, endurance, and oxidative capacity. However, the 3D structural …

Mitochondria play a key role in cellular signalling, metabolism and energetics. Proper
architecture and remodelling of the inner mitochondrial membrane are essential for efficient …

The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

The 'mitochondrial contact site and cristae organising system'(MICOS) is an essential protein
complex that promotes the formation, maintenance and stability of mitochondrial cristae. As …