Atrial fibrillation (AF) and heart failure (HF) contribute to about 45% of all cardiovascular
disease (CVD) deaths in the USA and around the globe. Due to the complex nature …

Cardiovascular disease (CVD) remains the leading cause of death worldwide. Natural
compounds extracted from medicinal plants characterized by diverse biological activities …

Abstract Background Brugada syndrome (BrS) is causing sudden cardiac death (SCD)
mainly at young age. Studying the underlying mechanisms associated with BrS type I …

Hundreds of thousands of people die each year as a result of sudden cardiac death, and
many are due to heart rhythm disorders. One of the major causes of these arrhythmic events …

With the discovery of induced pluripotent stem cell (iPSCs) a wide range of cell types,
including iPSC-derived cardiomyocytes (iPSC-CM), can now be generated from an …

The development of high-throughput automated patch-clamp technology is a recent
breakthrough in the field of Brugada syndrome research. Brugada syndrome is a heart …

Brugada syndrome is an inherited cardiac arrhythmia disorder that is mainly associated with
mutations of the cardiac voltage-gated sodium channel alpha subunit 5 (SCN5A) gene. The …

Brugada syndrome (BrS) is an inherited autosomal dominant cardiac channelopathy.
Pathogenic rare mutations in the SCN5A gene, encoding the alpha-subunit of the voltage …

Brugada syndrome (BrS) is a channelopathy, which is linked to sudden cardiac death at
young age. 1, 2 Patients may suffer from syncope, atrial fibrillation, sinus-nodedysfunction …

Background Brugada syndrome (BrS) is associated with ventricular tachyarrhythmias.
However, the presence of electrical strom (ES) and its management still debated. Objectives …