Sensorineural hearing loss impairs sensitivity but spares temporal integration for detection of frequency modulation

N Wallaert, L Varnet, BCJ Moore… - The Journal of the …, 2018 - pubs.aip.org
The effect of the number of modulation cycles (N) on frequency-modulation (FM) detection
thresholds (FMDTs) was measured with and without interfering amplitude modulation (AM) …

Perceptual Consequences of Cochlear Deafferentation in Humans

NF Bramhall, GP McMillan - Trends in Hearing, 2024 - journals.sagepub.com
Cochlear synaptopathy, a form of cochlear deafferentation, has been demonstrated in a
number of animal species, including non-human primates. Both age and noise exposure …

[HTML][HTML] New advances in electrocochleography for clinical and basic investigation

M Pienkowski, OF Adunka, JT Lichtenhan - Frontiers in neuroscience, 2018 - frontiersin.org
Electrocochleography (ECochG) is a technique for recording evoked potentials from the
inner ear, generally believed to originate from hair cells and nerve fibers. It is useful for …

Subclinical auditory dysfunction: Relationship between distortion product otoacoustic emissions and the audiogram

NF Bramhall, GP McMillan, AN Mashburn - American journal of audiology, 2021 - ASHA
Purpose Distortion product otoacoustic emissions (DPOAEs) and audiometric thresholds
have been used to account for the impacts of subclinical outer hair cell (OHC) dysfunction on …

Evidence of cochlear synaptopathy and the effect of systemic steroid in acute idiopathic tinnitus with normal hearing

E Park, I Song, YJ Jeong, GJ Im, HH Jung… - Otology & …, 2021 - journals.lww.com
Objective: To evaluate the electrophysiologic evidence of cochlear synaptopathy and the
effects of systemic steroids in acute idiopathic tinnitus with normal hearing. Study Design …

Pharmacotherapy of tinnitus

T Kleinjung, B Langguth - The Behavioral Neuroscience of Tinnitus, 2020 - Springer
Tinnitus is a common symptom for which there is in most cases no causal therapy. The
search for an improvement of tinnitus through pharmacological interventions has a long …

[HTML][HTML] Brainstem evoked auditory potentials in tinnitus: A best-evidence synthesis and meta-analysis

L Jacxsens, J De Pauw, E Cardon… - Frontiers in …, 2022 - frontiersin.org
Introduction Accumulating evidence suggests a role of the brainstem in tinnitus generation
and modulation. Several studies in chronic tinnitus patients have reported latency and …

Sodium salicylate improves detection of amplitude-modulated sound in mice

MM van den Berg, AB Wong, G Houtak, RS Williamson… - Iscience, 2024 - cell.com
Salicylate is commonly used to induce tinnitus in animals, but its underlying mechanism of
action is still debated. We therefore tested its effects on the firing properties of neurons in the …

Prolonged exposure of CBA/Ca mice to moderately loud noise can cause cochlear synaptopathy but not tinnitus or hyperacusis as assessed with the acoustic startle …

M Pienkowski - Trends in Hearing, 2018 - journals.sagepub.com
Hearing loss changes the auditory brain, sometimes maladaptively. When deprived of
cochlear input, central auditory neurons become more active spontaneously and begin to …

Comparison of silent gap in noise cortical auditory evoked potentials in matched tinnitus and no-tinnitus control subjects

K Morse, KR Vander Werff - American journal of audiology, 2019 - ASHA
Purpose Previous research suggests the existence of gap detection impairments because of
tinnitus. The current study aimed to determine whether there was objective evidence of gap …