Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have
significant cardiovascular morbidity and mortality that is in part due to the development of …

Background—Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone. In
chronic kidney disease (CKD), circulating FGF-23 levels are markedly elevated and …

The link between vascular calcification (VC) and increased mortality is now well established.
Over time, as clinical importance of this phenomenon has begun to be fully considered …

FGF23 is a bone-derived hormone that regulates systemic phosphate homeostasis, vitamin
D metabolism and α-Klotho expression through a novel bone-kidney axis. FGF23 inhibits …

Background and objectives: Levels of parathyroid hormone (PTH) and the phosphaturic
hormone FGF23, a fibroblast growth factor (FGF) family member, increase early in chronic …

Results FGF23 correlated directly with IL-6 (r= 0.4), CRP (r= 0.2), TNF-α (r= 0.4), and
fibrinogen (r= 0.3; P< 0.001 for each). In univariate and multivariable-adjusted linear …

Background. Fibroblast growth factor (FGF)-23, a novel bone-derived phosphaturic factor
involved in mineral metabolism, is increased in chronic kidney disease (CKD); in dialysis …

The discovery of fibroblast growth factor 23 (FGF-23) has expanded our understanding of
phosphate and vitamin D homeostasis and provided new insights into the pathogenesis of …

The hormone fibroblast growth factor 23 (FGF23) is involved in mineral homeostasis but may
also have a role in vascular calcification and bone mineralization. In a cohort of 142 patients …