Structural and functional properties of the evolutionarily ancient Y‐box family of nucleic acid binding proteins

AP Wolffe - Bioessays, 1994 - Wiley Online Library
The Y‐box proteins are the most evolutionarily conserved nucleic acid binding proteins yet
defined in bacteria, plants and animals. The central nucleic acid binding domain of the …

Crystal structure of CspA, the major cold shock protein of Escherichia coli.

H Schindelin, W Jiang, M Inouye… - Proceedings of the …, 1994 - National Acad Sciences
The major cold shock protein of Escherichia coli, CspA, produced upon a rapid downshift in
growth temperature, is involved in the transcriptional regulation of at least two genes. The …

[HTML][HTML] The major mRNA‐associated protein YB‐1 is a potent 5′ cap‐dependent mRNA stabilizer

V Evdokimova, P Ruzanov, H Imataka, B Raught… - The EMBO …, 2001 - embopress.org
mRNA silencing and storage play an important role in gene expression under diverse
circumstances, such as throughout early metazoan development and in response to many …

Gene regulation by Y-box proteins: coupling control of transcription and translation

K Matsumoto, AP Wolffe - Trends in cell biology, 1998 - cell.com
Y-box proteins are multifunctional regulators of gene expression. In somatic cells, they have
the capacity to exert positive and negative effects on both transcription and translation. In …

Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock protein

H Schindelin, MA Marahiel, U Heinemann - Nature, 1993 - nature.com
THE cold-shock response in both Escherichia coli and Bacillus subtilis is induced by an
abrupt downshift in growth temperature. It leads to the increased production of the major …

Role of the human Y box-binding protein YB-1 in cellular sensitivity to the DNA-damaging agents cisplatin, mitomycin C, and ultraviolet light

T Ohga, K Koike, M Ono, Y Makino, Y Itagaki… - Cancer research, 1996 - AACR
The Y box-binding protein (YB-1) binds to DNA sequences, present in the control regions of
many genes, that contain an inverted CCAAT box. The binding activity of a nuclear factor …

CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway

Y Zou, S Evans, J Chen, HC Kuo, RP Harvey… - …, 1997 - journals.biologists.com
To identify the molecular pathways that guide cardiac ventricular chamber specification,
maturation and morphogenesis, we have sought to characterize factors that regulate the …

Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene

T Ohga, T Uchiumi, Y Makino, K Koike, M Wada… - Journal of Biological …, 1998 - ASBMB
The human multidrug resistance 1 (MDR1) gene encoding P-glycoprotein is often
overexpressed in various human tumors after chemotherapy. During treatment with various …

A signature for the HMG‐1 box DNA‐binding proteins

D Landsman, M Bustin - Bioessays, 1993 - Wiley Online Library
A diverse group of DNA‐binding regulatory proteins share a common structural domain
which is homologous to the sequence of a highly conserved and abundant chromosomal …

YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …