Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical …

The effects of neurodegenerative syndromes extend beyond cognitive function to involve
key physiological processes, including eating and metabolism, autonomic nervous system …

Objective To determine the temporal sequence of objectively defined subtle cognitive
difficulties (Obj-SCD) in relation to amyloidosis and neurodegeneration, the current study …

Importance Small vessel cerebrovascular disease, visualized as white matter
hyperintensities (WMH), is associated with cognitive decline and risk of clinical Alzheimer …

Background Intranasally administered insulin has shown promise in both rodent and human
studies in Alzheimer's disease; however, both effects and mechanisms require elucidation …

White matter hyperintensities (WMHs), mainly caused by cerebrovascular injury, may lead to
cognitive impairment. In order to identify whether the volume of WMHs is associated with …

Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is
thought to play a role in the pathogenesis of cognitive disorders. Identifying the etiologies of …

Brain-age can be inferred from structural neuroimaging and compared to chronological age
(brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in …

Small vessel disease, a disorder of cerebral microvessels, is an expanding epidemic and a
common cause of stroke and dementia. Despite being almost ubiquitous in brain imaging …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by excessive
deposition of β amyloid (Aβ), hyperphosphorylation of tau protein, and neuronal cell death …