CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its
essential role in physiological activities in normal cells and pathological activities in cancer …

Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

Metabolic pathways involved in lactate metabolism are important to understand the
physiological response to exercise and the pathogenesis of prevalent diseases such as …

Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …

Adipose tissue metabolism is closely linked to insulin resistance, and differential fat
distributions are associated with disorders like hypertension, diabetes, and cardiovascular …

Acetylation has recently emerged as an important mechanism for controlling a broad array of
proteins mediating cellular adaptation to metabolic fuels. Acetylation is governed, in part, by …

The widespread epidemics of obesity and type 2 diabetes mellitus (T2DM) suggest that both
conditions are closely linked. An increasing body of evidence has shifted our view of …

Metabolic diseases represent a growing threat to world-wide public health. In general, these
disorders result from the interaction of heritable factors with environmental influences. Here …

The metabolic syndrome affects more than a third of the US population, predisposing to the
development of type 2 diabetes and cardiovascular disease. The 2009 consensus statement …

Cancer cells are characterized by self-sufficiency in the absence of growth signals, their
ability to evade apoptosis, resistance to anti-growth signals, sustained angiogenesis …