The concept of an ideal antibiotic: implications for drug design

M Gajdács - Molecules, 2019 - mdpi.com
The emergence and spread of antibiotic-resistant pathogens is a major public health issue,
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …

Interdisciplinary‐inspired smart antibacterial materials and their biomedical applications

Y Wu, P Liu, B Mehrjou, PK Chu - Advanced Materials, 2024 - Wiley Online Library
The discovery of antibiotics has saved millions of lives, but the emergence of antibiotic‐
resistant bacteria has become another problem in modern medicine. To avoid or reduce the …

Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle

J Salje - Nature Reviews Microbiology, 2021 - nature.com
The Rickettsiales are a group of obligate intracellular vector-borne Gram-negative bacteria
that include many organisms of clinical and agricultural importance, including Anaplasma …

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Polymeric Nanoparticles for Drug Delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Multi‐mode antibacterial strategies enabled by gene‐transfection and immunomodulatory nanoparticles in 3D‐printed scaffolds for synergistic exogenous and …

X Qu, M Wang, M Wang, H Tang, S Zhang… - Advanced …, 2022 - Wiley Online Library
As research on refractory Staphylococcus aureus‐related implant infection intensifies,
certain challenges remain, including low antibiotic concentrations within infected areas …

The history of colistin resistance mechanisms in bacteria: progress and challenges

M Hamel, JM Rolain, SA Baron - Microorganisms, 2021 - mdpi.com
Since 2015, the discovery of colistin resistance genes has been limited to the
characterization of new mobile colistin resistance (mcr) gene variants. However, given the …

Coating of a novel antimicrobial nanoparticle with a macrophage membrane for the selective entry into infected macrophages and killing of intracellular staphylococci

Y Li, Y Liu, Y Ren, L Su, A Li, Y An… - Advanced functional …, 2020 - Wiley Online Library
Internalization of Staphylococcus aureus by macrophages can inactivate bacterial killing
mechanisms, allowing intracellular residence and dissemination of infection. Concurrently …

Next-generation microbiology: from comparative genomics to gene function

CM Kobras, AK Fenton, SK Sheppard - Genome Biology, 2021 - Springer
Microbiology is at a turning point in its 120-year history. Widespread next-generation
sequencing has revealed genetic complexity among bacteria that could hardly have been …

An AIEgen‐peptide conjugate as a phototheranostic agent for phagosome‐entrapped bacteria

G Qi, F Hu, Kenry, L Shi, M Wu… - Angewandte Chemie …, 2019 - Wiley Online Library
The detection and elimination of intracellular bacteria remain a major challenge. In this work,
we report an aggregation‐induced emission (AIE) bioprobe that can detect bacterial …