Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives

E Khatoon, K Banik, C Harsha, BL Sailo… - Seminars in Cancer …, 2022 - Elsevier
Despite significant advancements made in the treatment of cancer during the past several
decades, it remains one of the leading causes of death worldwide killing approximately 9.6 …

Combination anticancer therapies using selected phytochemicals

WH Talib, D Awajan, RA Hamed, AO Azzam… - Molecules, 2022 - mdpi.com
Cancer is still one of the most widespread diseases globally, it is considered a vital health
challenge worldwide and one of the main barriers to long life expectancy. Due to the …

Thymoquinone, as a novel therapeutic candidate of cancers

B Almajali, HAN Al-Jamal, WRW Taib, I Ismail… - Pharmaceuticals, 2021 - mdpi.com
To date, natural products are widely used as pharmaceutical agents for many human
diseases and cancers. One of the most popular natural products that have been studied for …

Therapeutic implications and clinical manifestations of thymoquinone

M Alam, GM Hasan, MM Ansari, R Sharma, DK Yadav… - Phytochemistry, 2022 - Elsevier
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …

Importance of thymoquinone, sulforaphane, phloretin, and epigallocatechin and their health benefits

MH Shahrajabian, W Sun - Letters in Drug Design & Discovery, 2024 - ingentaconnect.com
Natural products have a broad diversity of multidimensional chemical formations, which play
an important role, and indicate the crucial nature as a golden source for gaining herbal drug …

[HTML][HTML] Thymoquinone and its pharmacological perspective: A review

S Tabassum, N Rosli, SJA Ichwan, P Mishra - … Research-Modern Chinese …, 2021 - Elsevier
Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally
and clinically used natural medicine. The diverse pharmacological properties of TQ have …

[HTML][HTML] Chemopreventive and anticancer effects of thymoquinone: cellular and molecular targets

R Gomathinayagam, JH Ha, M Jayaraman… - Journal of cancer …, 2020 - ncbi.nlm.nih.gov
Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that
are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have …

Tubulin degradation: Principles, agents, and applications

YF Zhang, J Huang, WX Zhang, YH Liu, X Wang… - Bioorganic …, 2023 - Elsevier
The microtubule system plays an important role in the mitosis and growth of eukaryotic cells,
and it is considered as an appealing and highly successful molecular target for cancer …

Effect of thymoquinone-loaded lipid–polymer nanoparticles as an oral delivery system on anticancer efficiency of doxorubicin

FA Moghaddam, M Ebrahimian, F Oroojalian… - Journal of nanostructure …, 2021 - Springer
In this study, thymoquinone (TQ) was encapsulated into lipid–polymer nanoparticles
(LPNPs) consisting of phosphatidylcholine (PC) and poly lactide–co-glycolide (PLGA) to …

Thymoquinone induces apoptosis of human renal carcinoma Caki-1 cells by inhibiting JAK2/STAT3 through pro-oxidant effect

IG Chae, NY Song, DH Kim, MY Lee, JM Park… - Food and Chemical …, 2020 - Elsevier
Currently, there are limited effective treatment options for renal cell carcinoma (RCC), due to
its poor responses to conventional therapies. Instead of using extrinsic anti-cancer drugs …