[HTML][HTML] Resistance to TKIs in EGFR-mutated non-small cell lung cancer: from mechanisms to new therapeutic strategies
Simple Summary Resistance to tyrosine kinase inhibitors (TKIs) of the epidermal growth
factor receptor (EGFR) in advanced mutant non-small cell lung cancer (NSCLC) constitutes …
factor receptor (EGFR) in advanced mutant non-small cell lung cancer (NSCLC) constitutes …
Brain metastases from non-small cell lung cancer with EGFR or ALK mutations: A systematic review and meta-analysis of multidisciplinary approaches
Background and purpose To analyze outcomes of non-small cell lung cancer (NSCLC)
patients with brain metastases harboring EGFR or ALK mutations and examine for …
patients with brain metastases harboring EGFR or ALK mutations and examine for …
[HTML][HTML] Experimental study of EGFR-TKI aumolertinib combined with ionizing radiation in EGFR mutated NSCLC brain metastases tumor
Y Zhang, Y Li, Y Han, M Li, X Li, F Fan, H Liu… - European Journal of …, 2023 - Elsevier
Aumolertinib is an irreversible third-generation epidermal growth factor receptor tyrosine
kinase inhibitor (EGFR-TKI), although it has been administered for the treatment of …
kinase inhibitor (EGFR-TKI), although it has been administered for the treatment of …
[HTML][HTML] Exploration of radiotherapy strategy for brain metastasis patients with driver gene positivity in lung cancer
Q Bi, X Lian, J Shen, F Zhang, T Xu - Journal of Cancer, 2024 - ncbi.nlm.nih.gov
Objective: To assess the disparities in effectiveness and identify outcome predictors in the
treatment of a targeted-first and radiotherapy-first regimen with driver gene-positive lung …
treatment of a targeted-first and radiotherapy-first regimen with driver gene-positive lung …
[HTML][HTML] EGFR-TKI plus brain radiotherapy versus EGFR-TKI alone in the management of EGFR-mutated NSCLC patients with brain metastases
K Dong, W Liang, S Zhao, M Guo, Q He… - Translational Lung …, 2019 - ncbi.nlm.nih.gov
Background It has been confirmed that epidermal growth factor receptor-tyrosine kinase
inhibitors (EGFR-TKIs) presented better efficacy than brain radiotherapy (brain RT) in the …
inhibitors (EGFR-TKIs) presented better efficacy than brain radiotherapy (brain RT) in the …
Improved survival and intracranial tumor control of EGFR-mutated NSCLC patients with newly developed brain metastases following stereotactic radiosurgery and …
Purpose To examine the differential effects of SRS and TKI on EGFR-mutated NSCLC
patients with brain metastases (BMs) and outcomes following continuation of the same TKI …
patients with brain metastases (BMs) and outcomes following continuation of the same TKI …
[HTML][HTML] First-line treatment with TKI plus brain radiotherapy versus TKI alone in EGFR-mutated non-small cell Lung cancer with brain metastases: a systematic review …
Y Song, S Lin, J Chen, J Dang - BMC cancer, 2023 - Springer
Background It remains uncertain whether first-line treatment with upfront brain radiotherapy
(RT) in combined with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR …
(RT) in combined with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR …
[HTML][HTML] Combination therapy of brain radiotherapy and EGFR-TKIs is more effective than TKIs alone for EGFR-mutant lung adenocarcinoma patients with …
Y Chen, J Wei, J Cai, A Liu - BMC cancer, 2019 - Springer
Background The treatment strategy for brain metastasis (BM) in patients with epidermal
growth factor receptor (EGFR)-mutant lung adenocarcinoma (LAC) remains controversial. In …
growth factor receptor (EGFR)-mutant lung adenocarcinoma (LAC) remains controversial. In …
[HTML][HTML] Clinical management of patients with non-small cell lung cancer, brain metastases, and actionable genomic alterations: a systematic literature review
M Khasraw, P Yalamanchili, A Santhanagopal… - Advances in …, 2024 - Springer
Introduction Nearly 60% of patients with non-small cell lung cancer (NSCLC) present with
metastatic disease, and approximately 20% have brain metastases (BrMs) at diagnosis …
metastatic disease, and approximately 20% have brain metastases (BrMs) at diagnosis …
EGFR‐mutated stage IV non‐small cell lung cancer: What is the role of radiotherapy combined with TKI?
B Liu, H Liu, Y Ma, Q Ding, M Zhang, X Liu… - Cancer …, 2021 - Wiley Online Library
Lung cancer is the leading cause of cancer‐related death globally and poses a
considerable threat to public health. Asia has the highest prevalence of epidermal growth …
considerable threat to public health. Asia has the highest prevalence of epidermal growth …