Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …

The lung epithelial lining serves as the primary barrier to inhaled environmental toxins,
allergens, and invading pathogens. Pulmonary fungal infections are devastating and carry …

Aspergillosis is a fungal infection caused by various species of Aspergillus, most notably A.
fumigatus. This fungus causes a spectrum of diseases, including allergic bronchopulmonary …

Background Aspergillus flavus, one of the causative agents of human fungal keratitis, can be
phagocytosed by human corneal epithelial (HCE) cells and the conidia containing …

Aspergillus fumigatus spores initiate more than 3,000,000 chronic and 300,000 invasive
diseases annually, worldwide. Depending on the immune status of the host, inhalation of …

The respiratory epithelium is highly complex, and its composition varies along the
conducting airways and alveoli. In addition to their primary function in maintaining the …

Damage to the lung epithelium is a unifying feature of disease caused by the saprophytic
fungus Aspergillus fumigatus. However, the mechanistic basis and the regulatory control of …

The immune system has to fight off hundreds of microbial invaders every day, such as the
human-pathogenic fungus Aspergillus fumigatus. The fungal conidia can reach the lower …

During the initiation of invasive aspergillosis, inhaled Aspergillus fumigatus conidia are
deposited on the epithelial cells lining the bronchi, terminal bronchioles, and alveoli. While …

Hundreds of spores of the common mould A spergillus f umigatus (Af) are inhaled daily by
human beings, representing a constant, often fatal, threat to our respiratory health. The small …