Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …

Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the
respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic …

The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …

Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …

The dissemination of tumor cells to local and distant sites presents a significant challenge in
the clinical management of many solid tumors. These cells may remain dormant for months …

Cigarette smoke (CS) leads to increased oxidative stress, inflammation, and exaggerated
senescence, which are involved in the pathogenesis of chronic obstructive pulmonary …

The extracellular matrix (ECM) is a dynamic structural network that provides a physical
scaffolding, as well as biochemical factors that maintain normal tissue homeostasis and thus …

Tissue repair and fibrosis, an abnormal form of repair, occur in most human organs in
response to injury or inflammation. Fibroblasts play a major role in the normal repair process …

COPD is driven by exogenous and endogenous oxidative stress derived from inhaled
cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria …

In fibrosis remodelling of ECM leads to changes in composition and stiffness. Such changes
can have a major impact on cell functions including proliferation, secretory profile and …