[HTML][HTML] Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

[HTML][HTML] COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

X Ren, W Wen, X Fan, W Hou, B Su, P Cai, J Li, Y Liu… - Cell, 2021 - cell.com
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …

[HTML][HTML] Mechanisms of SARS-CoV-2 transmission and pathogenesis

AG Harrison, T Lin, P Wang - Trends in immunology, 2020 - cell.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …

[HTML][HTML] From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human …

Z Zhu, X Lian, X Su, W Wu, GA Marraro, Y Zeng - Respiratory research, 2020 - Springer
Within two decades, there have emerged three highly pathogenic and deadly human
coronaviruses, namely SARS-CoV, MERS-CoV and SARS-CoV-2. The economic burden …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …

Bacterial and fungal coinfection in individuals with coronavirus: a rapid review to support COVID-19 antimicrobial prescribing

TM Rawson, LSP Moore, N Zhu… - Clinical infectious …, 2020 - academic.oup.com
Background To explore and describe the current literature surrounding bacterial/fungal
coinfection in patients with coronavirus infection. Methods MEDLINE, EMBASE, and Web of …

Patients with cancer appear more vulnerable to SARS-CoV-2: a multicenter study during the COVID-19 outbreak

M Dai, D Liu, M Liu, F Zhou, G Li, Z Chen, Z Zhang… - Cancer discovery, 2020 - AACR
The novel COVID-19 outbreak has affected more than 200 countries and territories as of
March 2020. Given that patients with cancer are generally more vulnerable to infections …

[HTML][HTML] A single-cell atlas of the peripheral immune response in patients with severe COVID-19

AJ Wilk, A Rustagi, NQ Zhao, J Roque… - Nature medicine, 2020 - nature.com
There is an urgent need to better understand the pathophysiology of Coronavirus disease
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …

[HTML][HTML] Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals

L Ni, F Ye, ML Cheng, Y Feng, YQ Deng, H Zhao… - Immunity, 2020 - cell.com
Summary The World Health Organization has declared SARS-CoV-2 virus outbreak a
worldwide pandemic. However, there is very limited understanding on the immune …