Natural sources and pharmacological properties of pinosylvin

S Bakrim, H Machate, T Benali, N Sahib, I Jaouadi… - Plants, 2022 - mdpi.com
Pinosylvin (3, 5-dihydroxy-trans-stilbene), a natural pre-infectious stilbenoid toxin, is a
terpenoid polyphenol compound principally found in the Vitaceae family in the heartwood of …

Biological valorization of lignin to flavonoids

HN Lan, RY Liu, ZH Liu, X Li, BZ Li, YJ Yuan - Biotechnology Advances, 2023 - Elsevier
Lignin is the most affluent natural aromatic biopolymer on the earth, which is the promising
renewable source for valuable products to promote the sustainability of biorefinery …

Production of plant-derived polyphenols in microorganisms: current state and perspectives

L Milke, J Aschenbrenner, J Marienhagen… - Applied Microbiology …, 2018 - Springer
Plants synthesize several thousand different polyphenols of which many have the potential
to aid in preventing or treating cancer, cardiovascular, and neurodegenerative diseases …

Biotechnological advances in resveratrol production and its chemical diversity

SB Thapa, RP Pandey, YI Park, JK Sohng - Molecules, 2019 - mdpi.com
The very well-known bioactive natural product, resveratrol (3, 5, 4′-trihydroxystilbene), is a
highly studied secondary metabolite produced by several plants, particularly grapes …

Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides

C Reimer, JE Kufs, J Rautschek, L Regestein… - Nature …, 2022 - nature.com
Aromatic polyketides are natural polyphenolic compounds with a broad spectrum of
pharmacological activities. Production of those metabolites in the model organisms …

A Combinatorial Approach to Optimize the Production of Curcuminoids From Tyrosine in Escherichia coli

JL Rodrigues, D Gomes, LR Rodrigues - Frontiers in Bioengineering …, 2020 - frontiersin.org
Curcuminoids are well-known for their therapeutic properties. However, their extraction from
natural sources is environmentally unfriendly, expensive and limited by seasonal variability …

Phenylalanine ammonia-lyase, a key component used for phenylpropanoids production by metabolic engineering

JQ Kong - RSC advances, 2015 - pubs.rsc.org
Phenylalanine ammonia-lyase (PAL, EC 4.3. 1.24) catalyzes the deamination of
phenylalanine to cinnamate and ammonia, the first step of the phenylpropanoid pathway …

Cinnamic acid derivatives as promising building blocks for advanced polymers: synthesis, properties and applications

AC Fonseca, MS Lima, AF Sousa, AJ Silvestre… - Polymer …, 2019 - pubs.rsc.org
Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose
structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them …

Synthetic biology-driven microbial production of resveratrol: advances and perspectives

C Feng, J Chen, W Ye, K Liao, Z Wang… - … in Bioengineering and …, 2022 - frontiersin.org
Resveratrol, a bioactive natural product found in many plants, is a secondary metabolite and
has attracted much attention in the medicine and health care products fields due to its …

Engineered microorganisms for the production of food additives approved by the European Union—A systematic analysis

N Kallscheuer - Frontiers in microbiology, 2018 - frontiersin.org
In the 1950s, the idea of a single harmonized list of food additives for the European Union
arose. Already in 1962, the E-classification system, a robust food safety system intended to …