Sepsis is a critical condition characterized by increased levels of pro-inflammatory cytokines
and proliferating cells such as neutrophils and macrophages in response to microbial …

Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting
in life-threatening organ dysfunction. Sepsis is a major public health concern associated …

Ischemia/reperfusion injury (IRI) is prone to occur after kidney transplantation, leading to
delayed graft function (DGF). MicroRNAs play a crucial role in the pathogenesis of …

Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles
(hucMSC-sEVs) have been demonstrated as a therapeutic agent to prevent and treat …

Sepsis-associated AKI is a life-threatening complication that is associated with high
morbidity and mortality in patients who are critically ill. Although it is clear early supportive …

Liensinine is mainly derived from alkaloids extracted and isolated from lotus seeds
(Nelumbo nucifera Gaertn). It possesses anti-inflammatory, and antioxidant, according to …

Inflammasomes are multiprotein complexes with an important role in the innate immune
response. Canonical activation of inflammasomes results in caspase-1 activation and …

Background Polarization of microglia, the resident retinal immune cells, plays important
roles in mediating both injury and repair responses post-retinal ischemia–reperfusion (I/R) …

Transplantation of pancreatic islet cells is a promising strategy for the long-term treatment of
type 1 diabetes (T1D). The stem cell-derived beta cells showed great potential as substitute …

Septic acute kidney injury (SAKI) is one of the most common and life-threatening
complications of sepsis. Patients with SAKI have increased mortality. However, the …