Targeted therapies in gynecological cancers: A comprehensive review of clinical evidence

Q Wang, H Peng, X Qi, M Wu, X Zhao - Signal Transduction and …, 2020 - nature.com
Advanced and recurrent gynecological cancers are associated with poor prognosis and lack
of effective treatment. The developments of the molecular mechanisms on cancer …

Systemic therapy in cervical cancer: 30 years in review

M Liontos, A Kyriazoglou, I Dimitriadis… - Critical reviews in …, 2019 - Elsevier
Advanced-inoperable cervical cancer is a challenging entity due to increased percentage of
locoregional and distant recurrences. Furthermore, recurrent cervical cancer not amenable …

[PDF][PDF] Safety and efficacy of pembrolizumab in advanced, programmed death ligand 1–positive cervical cancer: results from the phase Ib KEYNOTE-028 trial

JS Frenel, C Le Tourneau, B O'Neil… - Journal of Clinical …, 2017 - clf1.medpagetoday.com
Purpose The KEYNOTE-028 trial (ClinicalTrials. gov identifier: NCT02054806) was
designed to assess the safety and efficacy of pembrolizumab in 20 programmed death …

[HTML][HTML] Complete regression of metastatic cervical cancer after treatment with human papillomavirus–targeted tumor-infiltrating T cells

S Stevanović, LM Draper, MM Langhan… - Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
Purpose Metastatic cervical cancer is a prototypical chemotherapy-refractory epithelial
malignancy for which better treatments are needed. Adoptive T-cell therapy (ACT) is …

Treatment de‐escalation in HPV‐positive oropharyngeal carcinoma: ongoing trials, critical issues and perspectives

H Mirghani, F Amen, P Blanchard… - … journal of cancer, 2015 - Wiley Online Library
Due to the generally poor prognosis of head and neck squamous cell carcinoma (HNSCC),
treatment has been intensified, these last decades, leading to an increase of serious side …

[HTML][HTML] Cervical cancer therapies: Current challenges and future perspectives

CA Burmeister, SF Khan, G Schäfer, N Mbatani… - Tumour Virus …, 2022 - Elsevier
Cervical cancer is the fourth most common female cancer worldwide and results in over 300
000 deaths globally. The causative agent of cervical cancer is persistent infection with high …

Immunotherapy in cervical cancer

D Mauricio, B Zeybek, J Tymon-Rosario, J Harold… - Current oncology …, 2021 - Springer
Abstract Purpose of Review This review aims to summarize the current immunotherapy
studies and the potential targeted therapies showing promise in the treatment of cervical …

[HTML][HTML] Recurrent or primary metastatic cervical cancer: current and future treatments

C Gennigens, G Jerusalem, L Lapaille, M De Cuypere… - ESMO open, 2022 - Elsevier
Despite screening programs for early detection and the approval of human papillomavirus
vaccines, around 6% of women with cervical cancer (CC) are discovered with primary …

Targeted agents in cervical cancer: beyond bevacizumab

G Marquina, A Manzano, A Casado - Current oncology reports, 2018 - Springer
Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women
throughout the world. Approximately two thirds of the patients are diagnosed with locally …

Management of patients with recurrent/advanced cervical cancer beyond first line platinum regimens: Where do we stand? A literature review

S Boussios, E Seraj, G Zarkavelis, D Petrakis… - Critical reviews in …, 2016 - Elsevier
Background Cervical cancer is the fourth most common cancer affecting women worldwide.
Despite advances in screening and human papillomavirus (HPV) vaccination, a significant …