Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Enhanced GABAergic neurotransmission contributes to impairment of motor coordination
and gait and of cognitive function in different pathologies, including hyperammonemia and …

Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …

The neuropeptide cocaine-and amphetamine-regulated transcript (CART) has been
implicated in alcohol consumption and reward behaviours, yet mechanisms mediating these …

Positive effects of alcohol drinking such as anxiolysis and euphoria appear to be a crucial
factor in the initiation and maintenance of alcohol use disorder (AUD). However, the …

Background and Purpose A major problem managing alcohol use disorder is the high
vulnerability to relapse, even after long periods of abstinence. Chronic alcohol use …

Impairments in the function of the hypothalamic-pituitary-adrenal (HPA) axis and enhanced
glucocorticoid receptor (GR) activity in the central amygdala (CeA) are critical mechanisms …

Aberrant glucocorticoid signaling via glucocorticoid receptors (GR) plays a critical role in
alcohol use disorder (AUD). Acute alcohol withdrawal and protracted abstinence in …

The central nucleus of the amygdala is known to play key roles in alcohol use and affect.
Neurotensin neurons in the central nucleus of the amygdala have been shown to regulate …

Alcohol use disorder (AUD) is a chronically relapsing disease characterized by loss of
control in seeking and consuming alcohol (ethanol) driven by the recruitment of brain stress …