Antibody–drug conjugates in breast cancer: current status and future directions
C Mark, JS Lee, X Cui, Y Yuan - International Journal of Molecular …, 2023 - mdpi.com
Antibody drug conjugates (ADCs) are novel medications that combine monoclonal
antibodies with cytotoxic payloads, enabling the selective delivery of potent drugs to cancer …
antibodies with cytotoxic payloads, enabling the selective delivery of potent drugs to cancer …
The role of obesity in breast cancer pathogenesis
I Glassman, N Le, A Asif, A Goulding, CA Alcantara… - Cells, 2023 - mdpi.com
Research has shown that obesity increases the risk for type 2 diabetes mellitus (Type 2 DM)
by promoting insulin resistance, increases serum estrogen levels by the upregulation of …
by promoting insulin resistance, increases serum estrogen levels by the upregulation of …
Clinicopathological characteristics of HER2-low breast cancer: A retrospective study
M Yang, J Sun, L Liu, X Kong, D Lin, H Zhou, J Gao - Scientific reports, 2023 - nature.com
Abstract Human Epidermal Growth Factor Receptor-2 (HER2)-negative breast cancers
(BCs) contain HER2-low and HER2-zero ones. HER2-low breast cancer has been receiving …
(BCs) contain HER2-low and HER2-zero ones. HER2-low breast cancer has been receiving …
Recent Advances in Therapeutic Strategies to Improve Colorectal Cancer Treatment
WH Gmeiner - Cancers, 2024 - mdpi.com
Simple Summary Colorectal cancer is a leading cause of cancer mortality, and its incidence
is rapidly increasing worldwide. Colorectal cancer is considered a single entity based on …
is rapidly increasing worldwide. Colorectal cancer is considered a single entity based on …
Targeting HER3 to overcome EGFR TKI resistance in NSCLC
Q Chen, G Jia, X Zhang, W Ma - Frontiers in Immunology, 2024 - frontiersin.org
Receptor tyrosine kinases (RTKs) play a crucial role in cellular signaling and oncogenic
progression. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have …
progression. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have …
ErbB3 governs endothelial dysfunction in hypoxia-induced pulmonary hypertension
BACKGROUND: Pulmonary hypertension, characterized by vascular remodeling, currently
lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells …
lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells …
Receptor tyrosine kinases: Biological functions and anticancer targeted therapy
N Zhang, Y Li - Medcomm, 2023 - Wiley Online Library
Receptor tyrosine kinases (RTKs) are a class of protein kinases that play crucial roles in
various cellular processes, including cell migration, morphological differentiation, cell …
various cellular processes, including cell migration, morphological differentiation, cell …
Exploration and validation of key genes associated with early lymph node metastasis in thyroid carcinoma using weighted gene co-expression network analysis and …
Y Liu, Z Yin, Y Wang, H Chen - Frontiers in Endocrinology, 2023 - frontiersin.org
Background Thyroid carcinoma (THCA), the most common endocrine neoplasm, typically
exhibits an indolent behavior. However, in some instances, lymph node metastasis (LNM) …
exhibits an indolent behavior. However, in some instances, lymph node metastasis (LNM) …
Better safe than sorry: dual targeting antibodies for cancer immunotherapy
K Schoenfeld, J Harwardt, H Kolmar - Biological Chemistry, 2024 - degruyter.com
Antibody-based therapies are revolutionizing cancer treatment and experience a steady
increase from preclinical and clinical pipelines to market share. While the clinical success of …
increase from preclinical and clinical pipelines to market share. While the clinical success of …
Small molecular inhibitors: Therapeutic strategies for pancreatic cancer
Pancreatic cancer (PC), a disease with high heterogeneity and a dense stromal
microenvironment, presents significant challenges and a bleak prognosis. Recent …
microenvironment, presents significant challenges and a bleak prognosis. Recent …