[HTML][HTML] Enzyme therapy: current challenges and future perspectives

M de la Fuente, L Lombardero… - International Journal of …, 2021 - mdpi.com
In recent years, enzymes have risen as promising therapeutic tools for different pathologies,
from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint …

Pathogenesis and therapy of coagulation disorders in severe acute pancreatitis

M Gui, B Zhao, J Huang, E Chen, H Qu… - Journal of Inflammation …, 2023 - Taylor & Francis
Ischemia superimposed upon pancreatic edema leads to acute necrotizing pancreatitis. One
possible mechanism contributing to ischemia is intravascular thrombogenesis since fibrin …

[HTML][HTML] Hereditary Thrombophilia in the Era of COVID-19

OV Badulescu, PD Sirbu, N Filip, G Bordeianu… - Healthcare, 2022 - mdpi.com
Thrombophilia, also called hypercoagulability or prothrombotic condition, usually reflects a
certain imbalance that occurs either in the coagulation cascade or in the anticoagulation …

Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions

Q Cao, Z Hao, C Li, X Chen, M Gao, N Jiang… - Journal of Thrombosis …, 2023 - Elsevier
Background Inherited protein C deficiency (PCD) caused by mutations in protein C (PC)
gene (PROC) increases the risk of thrombosis. Missense mutations in PC's signal peptide …

[HTML][HTML] Domestication explains two-thirds of differential-gene-expression variance between domestic and wild animals; the remaining one-third reflects intraspecific …

I Chadaeva, P Ponomarenko, R Kozhemyakina… - Animals, 2021 - mdpi.com
Simple Summary Before genomes were sequenced, zoologists had discovered destabilizing
selection as a general pattern of animal domestication that in foxes and minks had yielded …

An Exploration of Anti-Inflammatory Therapy in Acute/Subacute Severe Cerebral Venous Thrombosis with Hereditary Protein C/S Deficiency: Case Series

W Hao, Y Gu, S Hu, X Ji, Y Wang… - Journal of Inflammation …, 2023 - Taylor & Francis
Background Inflammation was associated with the severity of severe cerebral venous
thrombosis (CVT) on admission and poor prognosis at discharge. Hereditary protein C/S …

[HTML][HTML] Acute myocardial infarction after initially diagnosed with unprovoked venous thromboembolism: A case report

J Seo, J Lee, YH Shin, AY Jang… - World Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Protein C deficiency is typically associated with venous thromboembolism;
however, arterial thrombosis has been reported in several cases. We report the case of a …

[HTML][HTML] Thrombosis associated with mycoplasma pneumoniae infection

J Liu, Y Li - Experimental and Therapeutic Medicine, 2021 - spandidos-publications.com
Mycoplasma pneumoniae is a common pathogen causing respiratory infections in children
and adults. In addition to respiratory diseases, Mycoplasma pneumoniae is also involved in …

A journey to vasculopathy in systemic sclerosis: focus on haemostasis and thrombosis

F Marongiu, MF Ruberto, S Marongiu… - Clinical and …, 2023 - Springer
Systemic sclerosis is a multisystem connective tissue disease, characterized by endothelial
autoimmune activation, along with tissue and vascular fibrosis leading to vasculopathy and …

Clinical impact of heritable thrombophilia on neonatal-onset thromboembolism: a nationwide study in Japan

N Egami, M Ochiai, M Ichiyama, H Inoue… - The Journal of …, 2021 - Elsevier
Objective To clarify the incidence and genetic risk of neonatal-thromboembolism, we
conducted a nationwide study exploring the impact of thrombophilia on neonatal …