Abstract The phosphodiesterase 5 (PDE5) inhibitors, including sildenafil (Viagra™),
vardenafil (Levitra™), and tadalafil (Cialis™) have been developed for treatment of erectile …

Cancers are an extraordinarily heterogeneous collection of diseases with distinct genetic
profiles and biological features that directly influence response patterns to various treatment …

The overexpression of phosphodiesterase (PDE) 5 is frequently found in various human
cancers, such as those of the breast. However, PDE5's role in the tumor microenvironment is …

Purpose: By catalyzing cGMP hydrolysis, phosphodiesterase (PDE) 5 is a critical regulator of
its concentration and effects in different (patho) physiologic processes, including cancers. As …

Purpose: We investigated the in vitro inhibitory effects of avanafil, a novel, potent inhibitor of
phosphodiesterase-5, on 11 phosphodiesterases. We also studied its potentiation of penile …

Diabetes can be described as a syndrome of multiple closely related conditions induced by
a chronic state of hyperglycaemia resulting from defective insulin secretion, insulin action or …

Background: Phosphodiesterase 5 inhibitors (PDE5-Is) sildenafil, vardenafil, tadalafil and
the recently approved avanafil represent the first-line choice for both on-demand and …

Hepatocellular carcinoma (HCC) has emerged as one of the most common and lethal
cancers worldwide and is caused due to contamination of diets with aflatoxin B1 and chronic …

Introduction The efficacy of phosphodiesterase type 5 inhibitors (PDE5i) in treating lower
urinary tract symptoms is supported by the extremely high expression and activity of PDE5 in …

Introduction: ADMET (absorption, distribution, metabolism, excretion, and toxicity) profiling is
an important aspect of all drug developments. The pharmaceutical industry must always …