Regular exercise is a formidable regulator of insulin sensitivity and overall systemic
metabolism through both acute events driven by each exercise bout and through chronic …

Obesity is a complex disease that affects whole body metabolism and is associated with an
increased risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D). Physical …

An ever-growing volume of peer-reviewed publications speaks to the recent and rapid
growth in both scope and understanding of exercise immunology. Indeed, more than 95% of …

Metabolic disorders, such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver
disease, are characterized by chronic low-grade tissue and systemic inflammation. During …

NAD+, a co-enzyme involved in a great deal of biochemical reactions, has been found to be
a network node of diverse biological processes. In mammalian cells, NAD+ is synthetized …

Chronic, systemic inflammation is an independent risk factor for several major clinical
diseases. In obesity, circulating levels of inflammatory markers are elevated, possibly due to …

Aging results in chronic low grade inflammation that is associated with increased risk for
disease, poor physical functioning and mortality. Strategies that reduce age-related …

Purpose: Recent studies suggest that exchange of macrophage phenotype (M1/M2) in
adipose tissue is associated with chronic low-grade inflammation in obesity. M1 …

The hydrolysis of ATP drives virtually all of the energy-requiring processes in living cells. A
prerequisite of living cells is that the concentration of ATP needs to be maintained at …

Background—Inflammatory processes are putative mechanisms underlying the
cardioprotective effects of physical activity. An inverse association between physical activity …