Leishmaniasis and Chagas disease are endemic pathologies in tropical countries. These
cause high morbidity and a public health problem. Current chemotherapies are based on …

Several pathologies, such as pain and inflammation, are modulated by different pathways,
making it necessary to develop drugs capable of modulating different pathways. Based on …

Developing new procedures for the synthesis of tetrahydropyrans in a very stereoselective
manner is of great importance for the synthesis of THP-containing natural products. Here, we …

Following our previously reported Prins cyclization strategy, a series of novel and highly
functionalized flavonoid based THPs (Prins products) were designed, synthesized and …

We present in this article syntheses of six new hybrids compounds (4–9) that were efficiently
prepared in one or two steps (70–84.6%) from our previous prototype (±)-cis-4-chloro-6 …

Benzoylacetone (1) underwent a series of multi-component reactions with aromatic
aldehydes and malononitrile or ethyl cyanoacetate to produce the pyran derivatives 4a-f …

In this paper we present the convenient syntheses of six new guanylhydrazone and
aminoguanidine tetrahydropyran derivatives 2–7. The guanylhydrazone 2, 3 and 4 were …

A direct and general method for the synthesis of naturally occurring 2, 3, 4, 5, 6-
pentasubstituted tetrahydropyrans has been developed, employing β, γ-unsaturated N-acyl …

Leishmaniases are a group of neglected tropical diseases (NTDs) caused by protozoan
parasites from> 20 Leishmania species. Visceral leishmaniasis (VL), also known as kala …

The iodine-catalyzed Prins cyclization of homoallylic alcohols and aldehydes was
investigated under metal-free conditions and without additives. Anhydrous conditions and …