G protein-coupled receptors (GPCRs) are central mediators of cell signaling and
physiological function. Despite their biological significance, GPCRs have not been widely …

Abstract Melatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to
membrane receptors. Several receptor subtypes exist in different species, of which the …

Melatonin, a neurohormone secreted by the pineal gland and regulated by the
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …

Cysteinyl leukotriene G protein-coupled receptors, CysLT1R and CysLT2R, regulate
bronchoconstrictive and pro-inflammatory effects and play a key role in allergic disorders …

In mammals, including humans, the neurohormone melatonin is mainly secreted from the
pineal gland at night and acts on two high-affinity G protein-coupled receptors, the melatonin …

Glaucoma, a major ocular neuropathy originating from a progressive degeneration of retinal
ganglion cells, is often associated with increased intraocular pressure (IOP). Daily IOP …

Virtual ligand screening (VLS) against high-resolution structures of G-protein-coupled
receptors (GPCRs) is likely to become the next-generation drug design approach of choice …

Melatonin, the hormone of darkness, is secreted in minute amounts during the night and is
virtually undetectable during the day. Melatonin mainly acts on high-affinity G protein …

Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …

Circadian rhythms are responsible for regulating a number of physiological processes. The
central oscillator is located within the suprachiasmatic nucleus (SCN) of the hypothalamus …