The search for melatonin receptor agonists formed the main part of melatonin medicinal
chemistry programs for the last three decades. In this short review, we summarize the two …

G protein-coupled receptors (GPCRs) constitute the largest family of druggable genes in the
human genome. Even though perhaps 30% of approved medications target GPCRs, they …

Abstract “Molecular Glues” are defined as small molecules that can either be endogenous or
synthetic which promote interactions between proteins at their interface. Allosteric …

G protein-coupled receptors (GPCRs) comprise the most important superfamily of protein
targets in current ligand discovery and drug development. GPCRs are integral membrane …

Melatonin (MLT) is an indolamine that presents a functional activity with a broad spectrum of
action, highlighting its antioxidant, anti-inflammatory and immunomodulatory and anti …

There is renewed interest in docking campaigns for ligand-discovery since the advent of
ultra-large scale virtual libraries. Using brute-force search, the scale of the libraries suggests …

The σ2 receptor is a poorly understood transmembrane receptor that has attracted intense
interest in many areas of biology including cancer imaging, Alzheimer's disease …

G protein-coupled receptors (GPCRs) constitute the largest family of druggable genes in the
human genome. Even though perhaps 30% of approved medications target GPCRs, they …

Machine learning represents a milestone in data-driven research, including material
informatics, robotics, and computer-aided drug discovery. With the continuously growing …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that possesses a
wide range of biological effects. Most of the main recognized effects of this hormone in …