Despite its apparent simplicity, the nematode worm Caenorhabditis elegans has developed
into an important model for biomedical research, particularly in the functional …

Many of the anthelmintic drugs in use today act on the nematode nervous system. Ion
channel targets have some obvious advantages. They tend to act quickly, which means that …

Egg-laying behavior in Caenorhabditis elegans is activated by signaling through the G-
protein Gρq and inhibited by signaling through a second G-protein, Gρo. Activation of egg …

GABA synapses play a critical role in many aspects of circuit development and function. For
example, conditions that perturb GABA transmission have been implicated in epilepsy. To …

Egg-laying behavior of the Caenorhabditis elegans hermaphrodite is regulated by G protein
signaling pathways. Here we show that the egg laying–defective mutant egl-6 (n592) carries …

Genetic studies of behavior in the nematode Caenorhabditis elegans have provided an
effective approach to investigate the molecular and cellular basis of nervous system function …

The nematode Caenorhabditis elegans joins the menagerie of behavioral model systems
next to the fruit fly Drosophila melanogaster, the marine snail Aplysia californica and the …

Neurotransmitter released from presynaptic terminals activates both ligand-gated ion
channels (ionotropic receptors) and a variety of G-protein-coupled receptors (GPCRs) …

Neurotransmitters signal via G protein coupled receptors (GPCRs) to modulate activity of
neurons and muscles. C. elegans has∼ 150 G protein coupled neuropeptide receptor …

Selenium is an essential micronutrient required for cellular antioxidant systems, yet at higher
doses it induces oxidative stress. Additionally, in vertebrates environmental exposures to …