This article presents an overview of time-resolved (lifetime) fluorescence techniques used in
biomedical diagnostics. In particular, we review the development of time-resolved …

Background Fluorescence-guided surgery (FGS) is a technique used to enhance
visualization of tumor margins in order to increase the extent of tumor resection in glioma …

The determination of brain tumor margins both during the presurgical planning phase and
during surgical resection has long been a challenging task in the therapy of brain tumor …

Although noninvasive, continuous monitoring of glucose concentration in blood and tissues
is one of the most challenging areas in medicine, a wide range of optical techniques has …

Diffuse reflectance spectroscopy in the visible and NIR spectral ranges is an effective and
extensively used technique for the non-invasive study and characterization of various …

Various tumor types exhibit the spectral fingerprints in the absorption and reflection spectra
in visible and especially in near-to short-wave-infrared wavelength ranges. For the purpose …

When light is incident to a biological tissue surface, combinations of optical processes occur,
such as reflection, absorption, elastic and non-elastic scattering, and fluorescence. Analysis …

We demonstrate for the first time the application of an endoscopic fluorescence lifetime
imaging microscopy (FLIM) system to the intraoperative diagnosis of glioblastoma …

Biomarkers are indicators of biological processes and hold promise for the diagnosis and
treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked …

Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering,
biophysics, computer science, medicine, biology, and chemistry, helping us understand light …