The protective role of resveratrol in myocardial ischemia/reperfusion is not well understood.
The aim of this study was to investigate whether resveratrol modulates inflammation and …

The protein Keap1 is central to the regulation of the Nrf2-mediated cytoprotective response,
and is increasingly recognized as an important target for therapeutic intervention in a range …

Alveolar cell apoptosis is involved in the pathogenesis of emphysema, a prevalent disease
primarily caused by cigarette smoking. We report that ceramide, a second messenger lipid …

Nrf2, a redox sensitive transcription factor, plays a pivotal role in redox homeostasis during
oxidative stress. Nrf2 is sequestered in cytosol by an inhibitory protein Keap1 which causes …

The incidence of lung diseases and cancer caused by cigarette smoke is increasing. The
molecular mechanisms of gene regulation induced by cigarette smoke that ultimately lead to …

Nuclear factor erythroid-2–related factor 2 (Nrf2) is a redox-sensitive transcription factor that
regulates the expression of electrophile and xenobiotic detoxification enzymes and efflux …

Chronic obstructive pulmonary disease (COPD) is a global health problem. The current
therapies for COPD are poorly effective and the mainstays of pharmacotherapy are …

Rationale: Germline mutations in the enzyme telomerase cause telomere shortening, and
have their most common clinical manifestation in age-related lung disease that manifests as …

Objectives: To determine the link between severity of COPD, oxidative stress, and NRF2-
dependent antioxidant levels in the peripheral lung tissue of patients with COPD. Methods …

Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory
diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD) …