The homeostasis of bone microenvironment is the foundation of bone health and comprises
2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In …

Ovarian aging occurs prior to the aging of other organ systems and acts as the pacemaker of
the aging process of multiple organs. As life expectancy has increased, preventing ovarian …

ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) have been established
drug targets for decades, with their inhibitors and activators possessing relevant …

Our previous studies demonstrated that L-octaarginine grafted onto hyaluronic acid via a
tetraglycine spacer significantly enhanced intranasal absorption of protein drugs with a …

Osteoporosis is a metabolic bone disease that impairs bone mineral density,
microarchitecture, and strength. It requires continuous management, and further research …

Nowadays, the treatment of musculoskeletal diseases represents a major challenge in the
developed world. Diseases such as osteoporosis, osteoarthritis and arthritis have a high …

Sports participation and the risk of osteoarthritis (OA) have been a concern for decades. Few
research efforts have been dedicated to clarify this issue for females, although they are …

Osteoporosis (OP) is a chronic systemic bone metabolism disease characterized by
decreased bone mass, microarchitectural deterioration, and fragility fractures. With the …

Osteoporosis, which is often associated with increased osteoclast activity due to menopause
or aging, was the main focus of this study. We investigated the inhibitory effects of water …

Reduced expression of the plasma membrane citrate transporter SLC13A5, also known as
INDY, has been linked to increased longevity and mitigated age-related cardiovascular and …