[HTML][HTML] Transporter-mediated drug delivery
G Gyimesi, MA Hediger - Molecules, 2023 - mdpi.com
Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
Small-molecule drugs for cystic fibrosis: Where are we now?
The cystic fibrosis (CF) lung disease is due to the lack/dysfunction of the CF Transmembrane
Conductance Regulator (CFTR), a chloride channel expressed by epithelial cells as the …
Conductance Regulator (CFTR), a chloride channel expressed by epithelial cells as the …
[HTML][HTML] Amino Acid Transporter SLC6A14 (ATB0,+) – A Target in Combined Anti-cancer Therapy
KA Nałęcz - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Cancer cells are characterized by quick growth and proliferation, demanding constant
supply of various nutrients. Several plasma membrane transporters delivering such …
supply of various nutrients. Several plasma membrane transporters delivering such …
[HTML][HTML] Intestinal amino acid transport and metabolic health
S Bröer - Annual review of nutrition, 2023 - annualreviews.org
Amino acids derived from protein digestion are important nutrients for the growth and
maintenance of organisms. Approximately half of the 20 proteinogenic amino acids can be …
maintenance of organisms. Approximately half of the 20 proteinogenic amino acids can be …
[HTML][HTML] Transport of L-arginine related cardiovascular risk markers
S Banjarnahor, RN Rodionov, J König… - Journal of Clinical …, 2020 - mdpi.com
L-arginine and its derivatives, asymmetric and symmetric dimethylarginine (ADMA and
SDMA) and L-homoarginine, have emerged as cardiovascular biomarkers linked to …
SDMA) and L-homoarginine, have emerged as cardiovascular biomarkers linked to …
[HTML][HTML] Modifier factors of cystic fibrosis phenotypes: a focus on modifier genes
Although cystic fibrosis (CF) is recognized as a monogenic disease, due to variants within
the CFTR (Cystic Fibrosis Transmembrane Regulator) gene, an extreme clinical …
the CFTR (Cystic Fibrosis Transmembrane Regulator) gene, an extreme clinical …
Genetic modifiers of cystic fibrosis lung disease severity: whole-genome analysis of 7,840 patients
Rationale: Lung disease is the major cause of morbidity and mortality in persons with cystic
fibrosis (pwCF). Variability in CF lung disease has substantial non-CFTR (CF …
fibrosis (pwCF). Variability in CF lung disease has substantial non-CFTR (CF …
[HTML][HTML] SLC6A14 facilitates epithelial cell ferroptosis via the C/EBPβ-PAK6 axis in ulcerative colitis
Y Chen, W Yan, Y Chen, J Zhu, J Wang, H Jin… - Cellular and Molecular …, 2022 - Springer
Emerging evidence suggests that ferroptosis is involved in the pathogenesis of ulcerative
colitis (UC). However, the key regulator of this process remains uncertain. In this study, we …
colitis (UC). However, the key regulator of this process remains uncertain. In this study, we …
[HTML][HTML] Carnitine traffic in cells. Link with cancer
Metabolic flexibility is a peculiar hallmark of cancer cells. A growing number of observations
reveal that tumors can utilize a wide range of substrates to sustain cell survival and …
reveal that tumors can utilize a wide range of substrates to sustain cell survival and …
[HTML][HTML] SLC6A14 deficiency is linked to obesity, fatty liver, and metabolic syndrome but only under conditions of a high-fat diet
SLC6A14 is a Na+/Cl−-coupled transporter for neutral/cationic amino acids, expressed in
ileum and colon. A single-nucleotide polymorphism (SNP), rs2011162 (− 22,510 C> G), in …
ileum and colon. A single-nucleotide polymorphism (SNP), rs2011162 (− 22,510 C> G), in …