The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …

Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

The extracellular matrix regulates tissue development and homeostasis, and its
dysregulation contributes to neoplastic progression. The extracellular matrix serves not only …

The extracellular matrix (ECM) is an important component of the tumor microenvironment
(TME), having several important roles related to the hallmarks of cancer. In cancer, multiple …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The field of tissue engineering continues to expand and mature, and several products are
now in clinical use, with numerous other preclinical and clinical studies underway. However …

Solid tumors are characterized by a remodeled and stiffened extracellular matrix. The
extracellular matrix is not a passive by-product of the tumor, but actively compromises tissue …

Electrospun polycaprolactone (PCL) tissue engineering scaffolds have been developed and
used for a wide range of tissue engineering applications, where successful incorporation …

Biophysical cues influence many aspects of cell behavior. Stiffness of the extracellular matrix
is probed by cells and transduced into biochemical signals through mechanotransduction …

Angiogenesis is de novo capillary outgrowth from pre-existing blood vessels. This process
not only is crucial for normal development, but also has an important role in supplying …