Brugada syndrome (BrS) is an inherited cardiac disorder, characterised by a typical ECG
pattern and an increased risk of arrhythmias and sudden cardiac death (SCD). BrS is a …

Congenital heart disease (CHD) affects~ 1% of all live births, but a definitive etiology is
identified in only~ 50%. The causes include chromosomal aneuploidies and copy-number …

Brugada syndrome (BrS) is diagnosed by a coved-type ST-segment elevation in the right
precordial leads on the electrocardiogram (ECG), and it is associated with an increased risk …

Brugada syndrome is a rare inherited arrhythmogenic disease leading to ventricular
fibrillation and high risk of sudden death. In 1998, this syndrome was linked with a genetic …

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by
high propensity to life-threatening arrhythmias and progressive loss of heart muscle. More …

In cardiomyocytes, the rapid depolarisation of the membrane potential is mediated by the α‐
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …

Background Genetic heart disease is a common cause of sudden cardiac arrest (SCA) in the
young and those without an ischaemic precipitant. Identifying a cause of SCA in these …

Hypertrophic cardiomyopathy (HCM) is the commonest genetic cardiomyopathy world-wide,
affecting approximately 1 in 500 individuals. Current therapeutic interventions comprise …

Background and Objectives Pathogenic variants at the voltage-gated sodium channel gene,
SCN8A, are associated with a wide spectrum of clinical disease outcomes. A critical …

Cardiomyopathies represent an important cause of heart failure, often affecting young
individuals, and have important implications for relatives. Genetic testing for …